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| Registros recuperados : 64 | |
| 7. |  | FERREIRA, M. I. C.; FONSECA, J. F. da; BRUSCHI, J. H.; FACO, O.; MENDONCA, L. C. Milk production and composition of Toggenburg and Toggenburg-Anglo Nubiana crossbred goats in Southeastern Brazil. In: INTERNATIONAL CONFERENCE ON GOATS, 11., 2012, Gran Canaria, Spain. Book of abstract... Little Rock, Arkansas: International Goat Association, 2012. p. 245.| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | FERREIRA, M. I. C.; FONSECA, J. F. da; BRUSCHI, J. H.; FACO, O.; MENDONCA, L. C. Milk production and composition of Toggenburg and Toggenburg-Anglo Nubiana crossbred goats in Southeastern Brazil. In: INTERNATIONAL CONFERENCE ON GOATS, 11., 2012, Gran Canaria, Spain. Book of abstract... Little Rock, Arkansas: International Goat Association, 2012. p. 245. Abstract M-47.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 11. | | FONSECA, J. F. da; MATOS, L. M.; ZAMBRINI, F. N.; FERREIRA, M. I. C.; FACO, O. hCG administration in Saanem goats inseminated following synchronized estrus. Animal Reproduction, v. 11, n. 3, p. 368, Jul./Sept. 2014. Abstract A088. Proceedings of the 28th Annual Meeting of The Brazilian Embryo Technology Society - SBTE, Natal, RN, Brasil, ago. 2014.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 13. | | BORGES, I.; GONÇALVES, L. C.; MACEDO JÚNIOR, G. de L.; FERREIRA, M. I. C. Utilização de subprodutos da agroindústria na alimentação de caprinos e ovinos. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL, 5; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 11.; SIMPÓSIO SERGIPANO DE PRODUÇÃO ANIMAL, 1., 2008, Aracaju. Anais... Aracaju: Sociedade Nordestina de Produção Animal; Embrapa Tabuleiros Costeiros, 2008. 13 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 16. | | BENEVIDES, Y. I.; CAMPOS, W. E; RODRIGUEZ, N. M.; MACEDO JUNIOR, G. L.; BORGES, I.; FERREIRA, M. I. C.; BRITO, T. S.; PIPES, C. P. Comportamento ingestivo de ovelhas submetidas ou não à restrição nutricional durante a gestação. Archivos Zootecnia, Cordoba, v. 60, n. 232, p. 891-901, 2011.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 17. | | ROGERIO, M. C. P.; FERREIRA, M. I. C.; BORGES, I.; XIMENES, L. J. F.; SILVA, V. L.; COSTA, H. H. A.; ARAÚJO, A. R. Alimentos alternativos e alimentação de caprinos e ovinos leiteiros. In: WORKSHOP SOBRE PRODUÇÃO DE CAPRINOS NA REGIÃO DA MATA ATLÂNTICA, 11., 2014, Coronel Pacheco. Anais... Brasília, DF: Embrapa, 2014. p. 11-36.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 18. | | PRATES, J. F.; OLIVEIRA, F. R. B. de; MAIA, A. L. R. de S.; PENIDO, P. P. do N.; FERREIRA, M. I. C.; FONSECA, J. F. da. Associação do efeito macho e duas doses cloprostenol para indução de estro sincronizados em ovelhas Santa Inês na região da Mata Atlântica de Minas Gerais. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 21., 2015, Belo Horizonte. Anais... Belo Horizonte: CBRA, 2015. p. 187.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 19. | | VIEIRA, F. A. P.; BORGES, I.; STEHLING, C. A. V.; GONCALVES, L. C.; COELHO, S. G. C.; FERREIRA, M. I. C.; RODRIGUES, J. A. S. Qualidade de silagens de sorgo com aditivos. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 56, n. 6, p. 764-772, dez. 2004.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 20. | | BALARO, M. F. A.; FONSECA, J. F. da; MAIA, A. L. R. S.; DELGADO, K. F.; FERREIRA, M. I. C.; BRANDÃO, F. Z. Protocolos hormonais de indução de estro sincronizado em ovelhas leiteiras na contra estação reprodutiva. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 20., 2013, Uberlandia. Anais... Belo Horizonte: CBRA, 2013. p. 81.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 64 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
06/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CHEN, Z.; HAGEN, D. E.; WANG, J.; ELSIK, C. G.; JI, T.; SIQUEIRA, L. G. B.; HANSEN, P. J.; RIVERA, R. M. |
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Afiliação: |
Zhiyuan Chen, University of Missouri, Columbia, MO, USA; Darren E. Hagen, University of Missouri, Columbia, MO, USA; Juanbin Wang, University of Missouri, Columbia, MO, USA; Christine G. Elsik, University of Missouri, Columbia, MO, USA; Tieming Ji, University of Missouri, Columbia, MO, USA; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; Peter J. Hansen, University of Florida, Gainesville, FL, USA; Rocio M. Rivera, University of Missouri, Columbia, MO. |
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Título: |
Global assessment of imprinted gene expression in the bovine conceptus by next generation sequencing. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Epigenetics, v. 11, n. 7, p. 501-516, 2016. |
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Idioma: |
Português |
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Conteúdo: |
Abstract Genomic imprinting is an epigenetic mechanism that leads to parental-allele-specific gene expression. Approximately 150 imprinted genes have been identified in humans and mice but less than 30 have been described as imprinted in cattle. For the purpose of de novo identification of imprinted genes in bovine, we determined global monoallelic gene expression in brain, skeletal muscle, liver, kidney and placenta of day ∼105 Bos taurus indicus × Bos taurus taurus F1 conceptuses using RNA sequencing. To accomplish this, we developed a bioinformatics pipeline to identify parent-specific single nucleotide polymorphism alleles after filtering adenosine to inosine (A-to-I) RNA editing sites. We identified 53 genes subject to monoallelic expression. Twenty three are genes known to be imprinted in the cow and an additional 7 have previously been characterized as imprinted in human and/or mouse that have not been reported as imprinted in cattle. Of the remaining 23 genes, we found that 10 are uncharacterized or unannotated transcripts located in known imprinted clusters, whereas the other 13 genes are distributed throughout the bovine genome and are not close to any known imprinted clusters. To exclude potential cis-eQTL effects on allele expression, we corroborated the parental specificity of monoallelic expression in day 86 Bos taurus taurus × Bos taurus taurus conceptuses and identified 8 novel bovine imprinted genes. Further, we identified 671 candidate A-to-I RNA editing sites and describe random X-inactivation in day 15 bovine extraembryonic membranes. Our results expand the imprinted gene list in bovine and demonstrate that monoallelic gene expression can be the result of cis-eQTL effects. MenosAbstract Genomic imprinting is an epigenetic mechanism that leads to parental-allele-specific gene expression. Approximately 150 imprinted genes have been identified in humans and mice but less than 30 have been described as imprinted in cattle. For the purpose of de novo identification of imprinted genes in bovine, we determined global monoallelic gene expression in brain, skeletal muscle, liver, kidney and placenta of day ∼105 Bos taurus indicus × Bos taurus taurus F1 conceptuses using RNA sequencing. To accomplish this, we developed a bioinformatics pipeline to identify parent-specific single nucleotide polymorphism alleles after filtering adenosine to inosine (A-to-I) RNA editing sites. We identified 53 genes subject to monoallelic expression. Twenty three are genes known to be imprinted in the cow and an additional 7 have previously been characterized as imprinted in human and/or mouse that have not been reported as imprinted in cattle. Of the remaining 23 genes, we found that 10 are uncharacterized or unannotated transcripts located in known imprinted clusters, whereas the other 13 genes are distributed throughout the bovine genome and are not close to any known imprinted clusters. To exclude potential cis-eQTL effects on allele expression, we corroborated the parental specificity of monoallelic expression in day 86 Bos taurus taurus × Bos taurus taurus conceptuses and identified 8 novel bovine imprinted genes. Further, we identified 671 candidate A-to-I RNA edit... Mostrar Tudo |
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Palavras-Chave: |
A-to-I RNA editing; Allele-specific gene expression; Next generation sequencing; X chromosome inactivation. |
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Thesaurus NAL: |
genomic imprinting. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/154835/1/Cnpgl-2016-Epigenetics-Global.pdf
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Marc: |
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100 1 $aCHEN, Z.
245 $aGlobal assessment of imprinted gene expression in the bovine conceptus by next generation sequencing.$h[electronic resource]
260 $c2016
520 $aAbstract Genomic imprinting is an epigenetic mechanism that leads to parental-allele-specific gene expression. Approximately 150 imprinted genes have been identified in humans and mice but less than 30 have been described as imprinted in cattle. For the purpose of de novo identification of imprinted genes in bovine, we determined global monoallelic gene expression in brain, skeletal muscle, liver, kidney and placenta of day ∼105 Bos taurus indicus × Bos taurus taurus F1 conceptuses using RNA sequencing. To accomplish this, we developed a bioinformatics pipeline to identify parent-specific single nucleotide polymorphism alleles after filtering adenosine to inosine (A-to-I) RNA editing sites. We identified 53 genes subject to monoallelic expression. Twenty three are genes known to be imprinted in the cow and an additional 7 have previously been characterized as imprinted in human and/or mouse that have not been reported as imprinted in cattle. Of the remaining 23 genes, we found that 10 are uncharacterized or unannotated transcripts located in known imprinted clusters, whereas the other 13 genes are distributed throughout the bovine genome and are not close to any known imprinted clusters. To exclude potential cis-eQTL effects on allele expression, we corroborated the parental specificity of monoallelic expression in day 86 Bos taurus taurus × Bos taurus taurus conceptuses and identified 8 novel bovine imprinted genes. Further, we identified 671 candidate A-to-I RNA editing sites and describe random X-inactivation in day 15 bovine extraembryonic membranes. Our results expand the imprinted gene list in bovine and demonstrate that monoallelic gene expression can be the result of cis-eQTL effects.
650 $agenomic imprinting
653 $aA-to-I RNA editing
653 $aAllele-specific gene expression
653 $aNext generation sequencing
653 $aX chromosome inactivation
700 1 $aHAGEN, D. E.
700 1 $aWANG, J.
700 1 $aELSIK, C. G.
700 1 $aJI, T.
700 1 $aSIQUEIRA, L. G. B.
700 1 $aHANSEN, P. J.
700 1 $aRIVERA, R. M.
773 $tEpigenetics$gv. 11, n. 7, p. 501-516, 2016.
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